. 2023 Jun 1;9(6):e16595. doi: 10.1016/j.heliyon.2023.e16595

Table 1.

Physicochemical properties of Roxadustat.

Chemical Structure of Roxadustat
IUPAC name	(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl) glycine 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl) amino] acetic acid
Appearance	White to Pale Green Solid
Chemical Formula	C₁₉H₁₆N₂O₅
Molecular Weight	352.3460
m/z:	352.1059 (100.0%), 353.1093 (20.5%), 354.1126 (2.0%), 354.1102 (1.0%)
CAS No.	808,118-40-3
Melting range	199–215 °C
Solubility	Slightly in water, 30 mg/mL DMSO, Ethanol
LogP	3.13, 1.85
pKa (Strongest Acidic)	2.75
pKa (Strongest Basic)	3.84
Index of Refraction	1.674