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. 2023 Jun 1;9(6):e16595. doi: 10.1016/j.heliyon.2023.e16595

Table 7.

Related substance and possible In-process Impurity of Roxadustat.

Compound name Exact mass (Da) Chemical Structure
5-phenoxyisobenzofuran-1(3H)-one
Chemical Formula:		 226.0630 Image 15
1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylic acid
Chemical Formula: C13H15FN2O3		 266.1067 Image 16
methyl 2-(chloromethyl)-4-phenoxybenzoate
Chemical Formula: C15H13ClO3		 276.0553 Image 17
1-(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)ethan-1-one
Chemical Formula: C18H15NO3		 293.1052 Image 18
methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Chemical Formula: C17H13NO4		 295.0845 Image 19
4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid 295.0845 Image 20
2,4-diphenoxybenzoic acid 306.0892 Image 21
methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate 309.1001 Image 22
ethyl 4-hydroxy-6-phenoxyisoquinoline-3-carboxylate 309.1001 Image 23
methyl 4-hydroxy-1-oxo-7-phenoxy-1,2-dihydroisoquinoline-3-carboxylate 311.0794 Image 24
4-hydroxy-3-(methoxycarbonyl)-7-phenoxyisoquinoline 2-oxide 311.0794 Image 25
methyl 1,4-dihydroxy-7-phenoxyisoquinoline-3-carboxylate 311.0794 Image 26
methyl 4-hydroxy-1-methyl-7-phenoxy-5,6,7,8-tetrahydroisoquinoline-3-carboxylate 313.1314 Image 27
methyl 4-hydroxy-1-methyl-7-phenoxy-4a,5,6,7,8,8a-hexahydroisoquinoline-3-carboxylate 315.1471 Image 28
ethyl 4-hydroxy-1-oxo-7-phenoxy-1,2-dihydroisoquinoline-3-carboxylate 325.0950 Image 29
methyl 7-(4-chlorophenoxy)-4-hydroxyisoquinoline-3-carboxylate 329.0455 Image 30
(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)glycine 338.0903 Image 31
methyl 7-(4-chlorophenoxy)-4-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylate 345.0404 Image 32
(E)-2-((1-(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)ethylidene)amino)acetic acid 350.1267 Image 33
(1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno [1,2-b]azirine-6a-carbonyl)glycine 352.1059 Image 34
(4-hydroxy-1-methyl-7-phenoxy-5,6,7,8-tetrahydroisoquinoline-3-carbonyl)glycine 356.1372 Image 35
(4-hydroxy-1-methyl-7-phenoxy-4a,5,6,7,8,8a-hexahydroisoquinoline-3-carbonyl)glycine 358.1529 Image 36
(1a-methyl-6-oxo-3-phenoxydecahydroindeno [1,2-b]azirine-6a-carbonyl)glycine 358.1529 Image 37
methyl (4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycinate 366.1216 Image 38
methyl 1-(acetoxymethyl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate 367.1056 Image 39
(4-hydroxy-1-(hydroxymethyl)-7-phenoxyisoquinoline-3-carbonyl)glycine 368.1008 Image 40
3-((carboxymethyl)carbamoyl)-4-hydroxy-1-methyl-7-phenoxyisoquinoline 2-oxide 368.1008 Image 41
methyl 1-(acetoxymethyl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate 367.1056 Image 42
(1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)glycine 372.0513 Image 43
(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycylglycine 409.1274 Image 44
methyl 1-(acetoxymethyl)-7-(4-chlorophenoxy)-4-hydroxyisoquinoline-3-carboxylate 401.0666 Image 45
benzyl (4-(benzyloxy)-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycinate 532.1998 Image 46
dimethyl 4,4′-dihydroxy-7,7′-diphenoxy-[1,8′-biisoquinoline]-3,3′-dicarboxylate 588.1533 Image 47