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. 2023 Jun 3;9(6):e16914. doi: 10.1016/j.heliyon.2023.e16914

Fig. 4.

Fig. 4

A. IL-1β level reduced in CAE, BET, PFD and BLM treated mice. Data were expressed as mean ± SEM with Dunnett’s multiple comparison test. N = 8, ####ρ < 0.0001 for BLM vrs naïve, ***ρ < 0.005 for 25, 50 mg/kg BET and 500 mg/kg vrs BLM, ****ρ < 0.0001 for 1000 mg/kg CAE vrs BLM. Bleomycin induced group – BLM, Crinum asiaticum bulbs extract – CAE, Betulin – BET and Pirfenidone – PFD.

B. IL-6 level reduced in CAE, BET, PFD and BLM treated mice. Data were expressed as mean ± SEM with Dunnett’s multiple comparison test. N = 8, ####ρ < 0.0001 for BLM vrs naïve, ****ρ < 0.0001 for 25, 50 mg/kg BET and 1000 mg/kg vrs BLM, ***ρ < 0.005 for 500 mg/kg CAE vrs BLM. Bleomycin induced group – BLM, Crinum asiaticum bulbs extract – CAE, Betulin – BET and Pirfenidone – PFD.

C. TNF-alpha level reduced in CAE, BET, PFD and BLM treated mice. Data were expressed as mean ± SEM with Dunnett’s multiple comparison test. N = 8, ####ρ < 0.0001 for BLM vrs naïve, ****ρ < 0.0001 for 50 mg/kg BET and 1000 mg/kg CAE vrs BLM, ***ρ < 0.005 for 500 mg/kg CAE vrs BLM. Bleomycin induced group – BLM, Crinum asiaticum bulbs extract – CAE, Betulin – BET and Pirfenidone – PFD.