Table 6.

Clinical trials of natural products as lipid-lowering agents (https://clinicaltrials.gov).

Compound	ClinicalTrials.gov Identifier	Type of study	Characteristics of patients (n)	Dose and time of treatment	Condition	Phase	Additional Refs
Catechin	NCT00692731	randomized, double-blind, controlled study	catechin group and control group	500 mL/day of a beverage providing approximately 625 mg catechins	overweight, obesity	–	[100]
Polyphenols	NCT05255367	open label	n = 26	Daily consumption of 100 mL of commercial berry and pomegranate juice, 20 g dark chocolate, and 1 green tea for 2 months to see if diet supplementation with (poly)phenol rich foods worked.	overweight, obesity	–
9-cis retinoic acid of Dunaliella bardawil	NCT00156169	randomized, double-blind, controlled study	Dunaliella group and control group n = 50	four Dunaliella capsules, providing 60 mg b-carotene per day after fibrate treatment	low HDL, cholesterol	phase 3	[23,235]
Exenatide	NCT01061775	open-label	n = 19	5mcg twice day for 4 weeks, then 10mcg twice daily for 20 weeks.	hypothalamic obesity	phase 1/2	[161]