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. 2023 Jun 6;13:1143950. doi: 10.3389/fcimb.2023.1143950

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Copyright © 2023 Gao, Mao, Zheng, Xu, Luo, Zhang, Liu, Wang, Chen and Dong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SJMHE1 accumulates in spleen and regulates the systemic immune response in AR mice. (A) Immunofluorescence of FITC-SJMHE1 (green) in nasal mucosa and spleen of mice at day 3, 7, and 14 after FITC-SJMHE1 treatment. Quantitative analysis for relative IL-4 (B), IL-13 (C) and IL-10 (D) genes expression in the spleen of mice. Data are presented as mean ± SD (n = 11) from two independent experiments. Each dot represents data from one animal. (E–G) Statistical analysis of IL-4, IL-13 and IL-10 levels in the serum, respectively. Data are presented as mean ± SD (n = 11) from three independent experiments. Each dot represents data from one animal. (H) OVA-specific IgE level in serum of mice. Data are presented as mean ± SD (n = 11) from three independent experiments. Each dot represents data from one animal. One-way analysis of variance (Tukey Kramer post hoc tests): *P<0.05, **P<0.01, ***P<0.001.