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. 2023 Jun 6;14:1149665. doi: 10.3389/fphar.2023.1149665

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Copyright © 2023 Zhang, Zhu, Yuan, Cheng, Xu, Chen, Pan and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathologic changes of the synovium in CIA and NAFLD rats. (A) In normal rats, synoviocytes were in monolayers (a) and articular cartilage was normal (b). (B) In CIA + NAFLD rats, serious proliferation of synoviocytes (a) and destruction of articular cartilage (b), with new blood vessels (or pannus) (c) and infiltration of inflammatory cells (d) were observed. (C) In NAFLD rats, there was slight destruction of articular cartilage (a), new blood vessels (b), pannus (c), and infiltration of inflammatory cells (d). (D) In CIA rats, destruction of articular cartilage (a), new blood vessels (b), pannus (c), and infiltration of inflammatory cells (d) were observed (b). Scale bar = 250 µm.