Fig. 6.

(A) In vivo treatment of osteosarcoma in each group of mice. (B) Tumor in vivo. (C) Tumor in vitro. (D) X-ray orthoimaging and measurement of experimental mice. (E) X-ray lateral view film and measurement of the changes in the tumor size. Changes in the (F) body weight, (G) tumor size, and (H) survival curves of the mice in each group (n ​= ​6, ∗P ​< ​0.05, ∗∗∗P ​< ​0.01). (I) In vivo anti-recurrence efficacy of the drug-loaded TS@PAP in the recurrent osteosarcoma model with Luc-labeled 143 ​B cells injected around the implant. (a) Third-day post cell injection, in vivo animal living fluorescence observation. (b) Tumor recurrence was fully controlled after another six days. (c) Following another cell injection, tumor recurrence was observed on day 12. (d) Tumor recurrence was partly controlled after another six days.