Fig. 2.

Plasma levels of Clusterin in Control and CDR≥1 individuals, with aging. Levels of plasma clusterin were assessed by immunoblotting and plotted according to the age of each individual. Pearson’s coefficient (Pearson r) was applied to test the correlation of both groups, (a) Controls (○) and (b) CDR≥1 (●), with aging. In Controls, (ns) stands for non-significant and p=0.1543; in CDR≥ 1, p=0.0003 (***). All samples were normalized to the reference sample and clusterin levels are represented as fold changes. Lines represent a linear regression fit with corresponding 95% confidence bands (dashed lines).