Table 4.
Hazard ratios and 95% confidence intervals for the joint association of polygenic risk score and the individual components of the healthy lifestyle score with lethal prostate cancer in the Health Professionals Follow-up Study.
| PRS quartile | HPFS (n = 10 443) | |||
|---|---|---|---|---|
| No. of events / Person-years of follow-up | HR (95% CI)a | No. of events / Person-years of follow-up | HR (95% CI)a | |
| Lethal prostate cancer | ||||
| Obese | Not Obese | |||
| 75–100% | 19/11977 | 1 (Ref.) | 78/90664 | 0.45 (0.27–0.76) |
| 50–75% | 9/15501 | 0.45 (0.20–1.01) | 66/98712 | 0.34 (0.19–0.58) |
| 25–50% | 6/16248 | 0.28 (0.11–0.73) | 41/106046 | 0.20 (0.11–0.35) |
| 0–25% | 6/14720 | 0.28 (0.11–0.71) | 26/113014 | 0.12 (0.07–0.23) |
| Smoke: Current or quit <10 yr | Smoke: Never or quit ≥10 yr | |||
| 75–100% | 12/11109 | 1 (Ref.) | 85/91532 | 0.67 (0.36–1.25) |
| 50–75% | 7/12743 | 0.47 (0.18–1.20) | 68/101470 | 0.49 (0.26–0.91) |
| 25–50% | 5/14600 | 0.33 (0.12–0.95) | 42/107694 | 0.29 (0.15–0.55) |
| 0–25% | 2/13267 | 0.14 (0.03–0.62) | 30/114467 | 0.20 (0.10–0.39) |
| Low/moderate vigorous physical activity | High vigorous physical activity | |||
| 75–100% | 86/75793 | 1 (Ref.) | 11/26848 | 0.50 (0.27–0.95) |
| 50–75% | 64/86869 | 0.66 (0.47–0.92) | 11/27344 | 0.46 (0.24–0.87) |
| 25–50% | 40/92066 | 0.40 (0.27–0.58) | 7/30228 | 0.28 (0.13–0.61) |
| 0–25% | 30/92957 | 0.29 (0.19–0.45) | 2/34777 | 0.07 (0.02–0.30) |
| Low/moderate tomato intake | High tomato intake | |||
| 75–100% | 81/80960 | 1 (Ref.) | 16/21681 | 0.86 (0.50–1.49) |
| 50–75% | 61/89590 | 0.67 (0.48–0.95) | 14/24622 | 0.68 (0.37–1.23) |
| 25–50% | 37/96322 | 0.40 (0.27–0.59) | 10/25972 | 0.43 (0.22–0.84) |
| 0–25% | 24/100524 | 0.25 (0.16–0.39) | 8/27210 | 0.38 (0.18–0.80) |
| High/moderate processed meat intake | Low processed meat intake | |||
| 75–100% | 30/25781 | 1 (Ref.) | 67/76860 | 0.84 (0.53–1.31) |
| 50–75% | 18/28695 | 0.52 (0.29–0.96) | 57/85517 | 0.64 (0.40–1.01) |
| 25–50% | 10/27586 | 0.29 (0.14–0.60) | 37/94708 | 0.40 (0.24–0.66) |
| 0–25% | 6/31619 | 0.17 (0.07–0.41) | 26/96115 | 0.27 (0.16–0.46) |
| Low/moderate fish intake | High fatty fish intake | |||
| 75–100% | 84/90677 | 1 (Ref.) | 13/11964 | 1.05 (0.58–1.91) |
| 50–75% | 65/100000 | 0.69 (0.49–0.97) | 10/14213 | 0.71 (0.36–1.40) |
| 25–50% | 41/106186 | 0.43 (0.30–0.63) | 6/16108 | 0.37 (0.16–0.86) |
| 0–25% | 23/108869 | 0.24 (0.15–0.38) | 9/18865 | 0.50 (0.25–1.01) |
Abbreviations: CI, confidence interval; HPFS, Health Professionals Follow-up Study; HR, hazard ratio; PRS, polygenic risk score.
a
Inverse probability weighted Cox regression models, stratified by birth cohort and adjusted for age (underlying time-scale), calendar period of inclusion, genetic ancestry (PC1-PC3), lagged PSA screening history, history of other cancers, history of diabetes, current aspirin use, current statin use, total energy intake, and each individual component.