Skip to main content
. 2023 Jun 19;13(6):e1300. doi: 10.1002/ctm2.1300

FIGURE 2.

FIGURE 2

Construction of lncRNA DUXAP8 / SLC7A11 signaling pathway. (A) GSEA of the KEGG pathway analysis showing enrichment of DUXAP8 in the lipid metabolism (left), ROS biosynthesis (Middle) and iron ion binding (right). (B) Pearson correlation analysis between the expression of LncRNA DUXAP8 and key ferroptosis regulators ACSL4, GPX4, and SLC7A11 from TCGA (left). The expression of LncRNA DXUAP8 was positively correlated with SLC7A11 mRNA expression (right). (C) Comparison of SLC7A11 expression between low‐ (n = 65) and high‐DUXAP8 (n = 44) patients by qRT‐PCR. (D) Cellular localization of SLC7A11(Red) visualized by immunofluorescence in LM3 cells. Magnification: ×400. * p < 0.05. The results represent the mean value from three independent experiments. sh‐DUX: sh‐DUXAP8; DUX: DUXAP8; ACS: ACSL4; GPX: GPX4; SLC: SLC7A11.