Figure 3.

T cell responses in NHPs immunized with MC3, KC2, and L319 LNPs loaded with unmodified and 1MpU-modified mRNA

4 weeks following the second immunization (D55), PBMCs were collected from the macaques and analyzed for (A) IFN-γ and (B) IL-13 secreting cells by FluoroSpot assay. Cell counts from each individual macaque are shown after subtracting counts obtained with PBMCs collected from the same animal pre-immunization. Each macaque can be identified on the graph with its symbol attributed in Figure 2. The bar represents the mean for the group.