Figure 4.

Innate responses in NHPs immunized with MC3, KC2, and L319 LNPs loaded with unmodified and 1MpU-modified mRNA

6 and 24 h following the first immunization, serum samples from macaques of Figure 2 were tested for innate chemokines/cytokines by MSD assay. Measured levels of (A) eotaxin, (B) MCP-1, (C) I-TAC, (D) IL-6, (E) IL-1RA, and (F) IFN-α2a are represented in pg/mL after subtracting background levels measured pre-immunization for each individual macaque identified by its symbol attributed in Figure 2. The bar represents the mean for the group. Levels of IL-1β, IL-8, and IL-17A did not increase over background and are not represented.