Figure 5.

Blood biomarkers in NHPs immunized with MC3, KC2, and L319 LNPs loaded with unmodified and 1MpU-modified mRNA

7 days before immunization (D-7) and 2 days following each immunization (D2, D30), plasma samples from the macaques were analyzed for standard blood parameters: alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, lipase, and C-reactive protein (CRP). Protein concentrations are shown for each individual macaque identified by its symbol attributed in Figure 2. Values are expressed in IU/L for ALP, ALT, AST, and lipase, in μmol/L for creatinine, and in mg/L for CRP. The bars represent the mean from each group. Lower and upper dashed lines in each graph represent the fifth and 95^th percentile, respectively, of reference pre-dose values commonly observed in cynomolgus macaques based on historical data. The fifth to 95^th percentile range covers 90% of these pre-dose data.