Efficacy of compound 4c in AD-induced rats using T-maze testa.
| Tested groups | Baseline (Sc) | Induction two months (Sc) | Treatment 4 weeks (Sc) |
|---|---|---|---|
| Control | 13.30 ± 1.00 | 14.80 ± 1.00 | 14.90 ± 1.00 |
| AlCl3-AD | 15.30 ± 1.10 | 50.90 ± 3.00 | — |
| % change | 1.53 | 243.92 | |
| AD-4c | — | — | 28.20 ± 1.80 |
| % improvement | 148.37 | ||
| Donepezil | — | — | 23.10 ± 1.70 |
| % improvement | 181.70 |
a
Data are expressed as mean SD (n = 10) in seconds. Groups with similar letters are not significantly different, while those with different letters are significantly different at p ≤ 0.05.