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. 2023 Mar 22;56(6):e13401. doi: 10.1111/cpr.13401

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© 2023 The Authors. Cell Proliferation published by European Cell Proliferation Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Gene Ontology and REACTOME analysis. Panel A: Venn diagram to identify common and specific SASP components among the different experimental conditions. Panel B: main GO and REACTOME outcomes. The SASP contained both factors, which were common among control and irradiated samples (see upper boxes), and proteins that were specifically present in a given sample (see lower boxes). Our analysis was carried out on whole secretomes containing soluble factors and molecules encapsulated within extracellular vesicles. Panel C: Network analysis. The top pictures show Minimum IMEx Interactome Networks with reduced complexity obtained by considering only seeds and their connecting nodes. The bottom images show representative seeds (node degree >20 and betweenness >200). Common: indicates seeds that are present in all irradiated samples (10D, 30D, 60D).