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Effects of DLE and MC on activation of STAT3 and LCN2 expression in IL-6-treated astrocytes. (A) Astrocytes were pretreated with DLE or MC for 1 h and subsequently stimulated with 10 ng/ml IL-6 for (B) 24 and (C) 4 h. Each bar represents the mean ± standard deviation (n=3). #P<0.05 vs. untreated cells. *P<0.05 vs. IL-6 alone. IP3R, inositol 1,4,5-trisphosphate receptor type 1; LCN2, lipocalin-2; DLE, Diospyros lotus leaf extract; MC, myricitrin; p-, phosphorylated.
