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. 2023 May 16;26(1):322. doi: 10.3892/etm.2023.12021

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Effect of Senp1-overexpression on mitochondrial membrane potential in HL-1 cells. (A) Compared with the control (dimethyl sulfoxide, 0.1%), the JC-1 ratio (aggregate/monomer) was decreased in 20 µmol/l ISO-induced HL-1 cells. AS-IV (50 µmol/l, n=7) prevented the ISO-induced decrease in the JC-1 ratio, which was inhibited by Senp1-overexpression (n=8). (B) Summarized data of the JC-1 ratio. Data are presented as the mean ± standard deviation. Two-way analysis of variance followed by Bonferroni’s test. *P<0.05 vs. control; #P<0.05 vs. HF; &P<0.05 vs. HF+AS-IV. Senp1, small ubiquitin-like modifier-specific protease 1; ISO, isoprenaline; AS-IV, astragaloside.