Table 2.
Characteristics of the BRaIN lab subjects
| 0 (n = 11) | 1 (n = 9) | 2 (n = 10) | 3 (n = 10) | Total (n = 40) | p value* | |
|---|---|---|---|---|---|---|
| Age, mean (SD) | 87.9 (7.9) | 91.4 (6.4) | 87.7 (5.5) | 90.1 (4.9) | 89.2 (6.3) | 0.51 |
| Sex, male | 5 (45%) | 5 (56%) | 5 (50%) | 4 (40%) | 19 (48%) | 0.97 |
| Year of death, mean (SD) | 2014 (5) | 2016 (4) | 2014 (4) | 2015 (5) | 2015 (4) | 0.87 |
| Postmortem time interval (hours), mean (SD) | 18.5 (22.8) | 16.8 (24.1) | 15.8 (17.0) | 12.9 (9.9) | 16.1 (18.6) | 0.93 |
| AD neuropathology | 0.26 | |||||
| N-Miss | 5 | 2 | 4 | 3 | 14 | |
| None/Low | 3 (50%) | 1 (14%) | 0 (0%) | 0 (0%) | 4 (15%) | |
| Med | 3 (50%) | 4 (57%) | 4 (67%) | 4 (57%) | 15 (58%) | |
| High | 0 (0%) | 2 (29%) | 2 (33%) | 3 (43%) | 7 (27%) | |
| Braak stage V–VI | 0.003 | |||||
| N-Miss | 0 | 0 | 1 | 0 | 1 | |
| 0–IV | 9 (82%) | 6 (67%) | 1 (11%) | 2 (20%) | 18 (46%) | |
| V–VI | 2 (18%) | 3 (33%) | 8 (89%) | 8 (80%) | 21 (54%) | |
| Hippocampal sclerosis | <0.001 | |||||
| N-Miss | 0 | 0 | 1 | 0 | 1 | |
| HS− | 10 (91%) | 9 (100%) | 4 (44%) | 2 (20%) | 25 (64%) | |
| HS+ | 1 (9%) | 0 (0%) | 5 (56%) | 8 (80%) | 14 (36%) | |
| Clinical dementia history | ||||||
| N-Miss | 1 | 1 | 0 | 1 | 3 | <0.001 |
| No | 9 (90%) | 5 (62%) | 1 (10%) | 0 (0%) | 15 (41%) | |
| Yes | 1 (10%) | 3 (38%) | 9 (90%) | 9 (100%) | 22 (59%) |
*
Based on ANOVA for age and the Fisher exact test for categorical variables.
BRaIN, University of Washington Biorepository and Integrated Neuropathology.