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. 2023 Jun 20;21:57. doi: 10.1186/s12958-023-01107-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Functional enrichment analysis of differentially expressed mRNAs. (A) The top 20 enriched GO terms in biological processes (BP) of downregulated dif-mRNAs. (B) The top 20 enriched GO terms in BP of upregulated dif-mRNAs. (C) The top 20 enriched KEGG pathway analyses process of downregulated dif-mRNAs. (D) The top 20 enriched KEGG pathway analyses process of upregulated dif-mRNAs. (E) The top 10 enriched GO terms of all dif-mRNAs in BP and associated dif-mRNAs were showed in chord diagram. (F) Dif-mRNAs typically involved in the GO terms of ncRNA process, DNA replication, mitotic sister chromatid segregation, and mitotic DNA replication. (G) GSEA showed dif-mRNAs in KEGG annotations for cell cycle, apoptosis, ECM-receptor interaction and cytokine-cytokine receptor interaction