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. 2023 Jun 20;21:57. doi: 10.1186/s12958-023-01107-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Construction of co-expression lncRNA–miRNA–mRNA networks in URSA and the functional enrichment analysis of mRNAs in ceRNA network. (A) Co-expression lncRNA–miRNA–mRNA networks in URSA. In this figure, lncRNA, miRNA, and mRNA were indicated by rectangle, triangle and octagon, respectively. (B) The hierarchical clustering heatmap of the 36 dif-mRNAs in ceRNA network. (C) The hierarchical clustering heat map of the 13 dif-lncRNAs in ceRNA network. (D) The top 10 significantly enriched GO terms in biological process of hub dif-mRNAs. (E) The top 10 enriched KEGG pathway of dif-mRNAs.