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. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: J Control Release. 2022 Aug 3;349:831–843. doi: 10.1016/j.jconrel.2022.07.041

Figure 6:

Figure 6:

DLin-MC3-DMA conjugate allows quantitative siRNA tissue retention and broad tissue distribution (A.) siRNA injected dose retained in tissues at 48h after SC injection of unconjugated (unconj), cholesterol, and DLin-MC3-DMA conjugated siRNAs (20 mg/kg, n=3, mean ± SD) (B.) Bar graph showing siRNA quantification in liver, kidney (cortex), and skin (injection site) measured by PNA hybridization assay (SC, 20 mg/kg, n=3, mean ± SD) (C.) Bar graph showing siRNA quantification in tissues measured by PNA hybridization assay (SC, 20 mg/kg, n=3, mean ± SD). Data analysis: Multiple comparisons = One-way ANOVA, Dunnett test (***P<0.001, **P<0.01, *P<0.1).