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. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: J Control Release. 2022 Aug 3;349:831–843. doi: 10.1016/j.jconrel.2022.07.041

Figure 8:

Figure 8:

DLin-MC3-DMA conjugate induced non-specific gene modulation in tissues accumulating >20 pmol siRNA/mg tissue. Observed Htt and Ppib mRNA silencing (A.) normalized to Hprt (an housekeeping gene) (B.) non normalized to Hprt in liver, kidney, and spleen after SC injection of DLin-MC3-DMA siRNAs (1 week, 20 mg/kg, n=5-6, mean ± SD) (C.) Bar graph showing Hprt mRNA silencing in liver, kidney, and spleen after SC injection of DLin-MC3-DMA siRNAs (1 week, 20 mg/kg, n=5-6, mean ± SD). Data analysis: Multiple comparisons = One-way ANOVA, Dunnett test (****P<0.0001, ***P<0.001, **P<0.01, *P<0.1).