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Superposition of a calmodulin-like protein undergoing a hinge motion. Structures 1 and 2 indicate the closed and open conformations, respectively. Compare ‘Global Fit’, the superposition produced by a traditional least-squares fit of the structures, to ‘Core1’ and ‘Core 2’, the two possible superpositions produced by sieve-fitting. The final panel depicts how a morph movie might appear using the ‘Core 2’ superposition.
