Fig. 5.
PD-1/PD-L1 blockade also reinvigorates tumor-blunted COVID-19 vaccine response in ICB-resistant tumor-engrafted mice. A. Schematic graph of the experiment design. B. B16F10 tumor growth curve of mice with or without anti-PD-L1 antibody treatment. C, D. ELISA binding assay of sera collected from mice at 10 days-post boost vaccination to SARS-CoV-2 prototype RBD (C) and Omicron RBD (D). E-F. Numbers of B cells (E), GC B cells (F) and TFH cells (G) in vaccine-dLNs. ns, not significant. *P < 0.05 and **P < 0.01. The data are representative of two independent experiments with six mice per group. Error bars (B-G) indicate s.e.m..