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. 2023 Apr 14;72(7):986–998. doi: 10.2337/db22-1014

Figure 4.

Figure 4

Normalization of ligature-induced experimental periodontitis in SMIRKO and HFD-fed mice by overexpression of intragingival adenoviral CXCL1. A: Eubacterial 16S expressions (N = 5); B: neutrophil populations (N = 5); C: CXCL1 (N = 5); D: TNFα (N = 5); and E: IL-1β mRNA expressions in the gingiva from WT, SMIRKO, and HFD-fed mice after ligations with intragingival adenoviral CMV or CXCL1 overexpression (N = 5). F: Representative photographs and G and H: net bone loss area of each mouse with intragingival adenoviral CMV or CXCL1 overexpression (N = 7–10). *P < 0.05, **P < 0.01, ***P < 0.001. Blue circle, WT (RD-fed); orange square, SMIRKO; yellow square, HFD-fed.