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. 2023 May 28;22(12):1496–1513. doi: 10.1080/15384101.2023.2216504

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Figure 4. — TRIM13 interacts with p62 protein in LUAD cells.

Note: (a) The PPI network of TRIM13 was predicted using String and BioGrid databases. Autophagy-related marker p62 (SQSTM1) showed a strong correlation with TRIM13. (b) The protein level of p62 was significantly reduced in oe-TRIM13-transfected LUAD cells compared to oe-NC, but no significant change was observed at the mRNA level as measured by RT-qPCR (upper graph) and western blot (lower graph). (c) Co-localization of P62 with TRIM13 in oe-NC- or oe-TRIM13-transfected LUAD cells was detected by immunofluorescence. (d) Co-IP experiments detected the interaction between P62 and TRIM13 in Flag-TRIM13- or HA-p62-transfected LUAD cells. * P < 0.05, ** P < 0.01, ***P < 0.001 were considered significant values, while “ns” indicates no significance.