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. 2023 Apr 11;10(6):nwad094. doi: 10.1093/nsr/nwad094

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© The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Common transcriptomic alterations of cancer cells compared with normal epithelial cells. (A) Schematic illustration of the study workflow. WCG, W denotes A or T. GCH, H denotes A, C or T. (B) The UMAP of all cancer cells and normal_epi_stomach based on scTrio-seq3 transcriptome data. (C) and (D) Highly expressed DEGs of normal_epi_stomach (C) and cancer cells (D). (E) and (F) The gene expression levels, DNA methylation levels and chromatin accessibility levels of related promoter regions of representative genes. The white diamonds represent the mean value of each group. Wilcoxon rank-sum test, ****P-value < 0.0001, ***P-value < 0.001, **P-value < 0.01, *P-value < 0.05.