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. 2023 Apr 11;10(6):nwad094. doi: 10.1093/nsr/nwad094

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© The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Cancer cells with different differentiation states show different immune states. (A) The GSVA scores of immune-related pathways in the hallmark pathways. The median values and interquartile ranges are shown. Wilcoxon rank-sum test, ****P-value < 0.0001, ***P-value < 0.001, **P-value < 0.01, *P-value < 0.05. n.s., not significant. (B) IHC staining of CD8 protein for some representative sampling positions of mGCs. Scale bars, 25 μm. (C) IHC staining of CD8 protein for an additional validation patient with MANEC.