Figure 5.

LOXL2 enhanced the proliferation and inhibited 5-FU-induced apoptosis in CRC cells. (A) The apoptosis rates of CRC cells treated with 5-FU at a concentration of 10 μM for 48 h were detected with the flow cytometry assays. The apoptosis rate was significantly decreased when LOXL2 was overexpressed and was significantly increased when LOXL2 was knocked down. LOXL2 or scramble stably downregulated SW48 cells were subcutaneously injected into the mice, and 5-FU treatment was conducted every 3 days. The tumor growth volume (B) and weight (C) were measured. Student’s t-test or two-way ANOVA and Tukey’s multiple comparison test were used for significance determination. Error bars, SD.

***p < 0.001, **p < 0.01, *p < 0.05.