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. 2022 Dec 27;248(6):457–468. doi: 10.1177/15353702221139203

Figure 9.

Figure 9.

Cyclopamine promoted CRC cells 5-FU sensitivity. Hedgehog/BCL2 signaling pathway-specific antagonists cyclopamine (40 nM) was used on HCT116 cells treated with 5-Fu (10 μM). (A) Cell viabilities were detected by the CCK8 assays in HCT116 cells at day 0, day 1, day 2, day 3, and day 4. (B) The apoptosis rates of CRC cells were detected by the flow cytometry assays. (C) Protein levels of SMO, GLI1, GLI2, and BCL2 in HCT116 were determined by Western blots.