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Dysfunctional hypertrophic adipocytes show blunted vitamin D signalling. Vitamin D receptor and the hydroxylase CYP27B1 are blunted in dysfunctional hypertrophic adipocyte. Alongside the sequestration of 25(OH)D within visceral adipose tissue, suppression of vitamin D signalling sustains metabolic disturbances not only in adipose tissue but also systemically.
