REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
BUV737 CD8a	BD	Cat#612759; RRID: AB_2870090
BV421 CD8a	BioLegend	Cat#100738; RRID: AB_11204079
BV605 CD44	BD	Cat#563058; RRID: AB_2737979
BUV395 Thy1.1	BD	Cat#563804; RRID: AB_2632398
BUV496 Thy1.2	BD	Cat#741046; RRID: AB_2870661
PE CD127	BioLegend	Cat#135010; RRID: AB_1937251
PE-Cy7 KLRG1	Invitrogen	Cat#25-5893-82; RRID: AB_1518768
PerCP-Cy5.5 CX3CR1	BioLegend	Cat#149010; RRID: AB_2564494
BUV395 CXCR3	BD	Cat#745689; RRID AB_2743174
BV711 CD49a	BD	Cat#564863: RRID: AB_2738987
BUV737 CD69	BD	Cat#564684; RRID: AB_2738891
BUV395 CD103	BD	Cat#740238; RRID: AB_2739985
BV480 Va2	BD	Cat#746615; RRID: AB_2743895
R718 TCRb	BD	Cat#567299
PE Tbet	BioLegend	Cat#644810; RRID: AB_2200542
PE-Cy7 Eomes	Invitrogen	Cat#25-4875-82; RRID: AB_2573454
AF647 Tcf1	Cell Signaling Technology	Cat#6709S
ARID1A	Abcam	Cat#ab182561
BV421 IFNg	BioLegend	Cat#505830; RRID: AB_2563105
PE-Cy7 TNF	BioLegend	Cat#506324; RRID: AB_2256076
APC CCL3	R&D Systems	Cat#IC450A
PE IL-2	BioLegend	Cat#503808; RRID: AB_315302
PE-Cy7 Granzyme B	Biolegend	Cat#372214; RRID: AB_2728381
PE Granzyme A	ThermoFisher Scientific	Cat#17-5831-82; RRID: AB_2573228
eBioscience™ Fixable Viability Dye eFluor™ 780	ThermoFisher Scientific	Cat#65-0865-14
CellTrace Violet	ThermoFisher Scientific	Cat#C34557
DAPI	BD	Cat#564907
H3K27ac	Abcam	Cat#4729
H3K27me3	Cell Signaling Technology	Cat#9733S
ARID1A	Cell Signaling Technology	Cat#12354S
BATF	Brookwood Biomed	Cat#4003
Tbet	Cell Signaling Technology	Cat#97135S
ETS1	Cell Signaling Technology	Cat#14069
Purified NA/LE Hamster anti-Mouse CD3e	BD	Cat#567114
Purified Hamster anti-Mouse CD28	BD	Cat#553295; RRID: AB_394764
Bacterial and virus strains
LCMV Armstrong	Kaech and Ahmed, 2001	NA
Listeria monocytogenes GP33-41	Ananda Goldrath	NA
Chemicals, peptides, and recombinant proteins
GP33-41 peptide	GenScript	Cat#RP20091
Recombinant Murine IL-12p70	R&D Systems	Cat#419-ML-010
Recombinant Murine IL-2	PEPROTECH	Cat# 212-12
Recombinant Murine IL-18	R&D Systems	Cat#9139-IL-010
ACBI1	opnMe	NA
BRM014	MedChemExpress	Cat#HY-119374
Brefeldin A	BioLegend	Cat#420601
ACK Lysing Buffer	VWR	Cat#10128-804
eBioscience Foxp3/Transcription factor staining buffer set	ThermoFisher Scientific	Cat#00-5523-00
eBioscience 10X Permeabilization buffer	ThermoFisher Scientific	Cat#00-8333-56
Cytofix/Cytoperm	BD	Cat#554714
RPMI 1640 Medium	GIBCO	Cat#21875034
Fetal bovine serum	Sigma-Aldrich	Cat#F0804
L-Glutamine	GIBCO	Cat#25030081
2-Mercaptoethanol	GIBCO	Cat#21985023
Penicillin-streptomycin	Invitrogen	Cat#15140148
Collegenase D	Sigma-Aldrich	Cat#11088882001
DnaseI	Sigma-Aldrich	Cat#DN25-5G
HBSS	GIBCO	Cat#14025092
Dithioerythritol	EMD Millipore	Cat#233152
1M HEPES	ThermoFisher Scientific	Cat#15630080
Alt-R S.p. Cas9 Nuclease V3	IDT	Cat#1081059
pA/G-MNase	Epicypher	Cat#14-1048
Critical commercial assays
P3 Primary Cell 4D X Kit S	Lonza	V4XP-3032
Deposited data
Raw and analyzed data	This paper	GEO: GSE228381
Experimental models: Organisms/strains
Mouse: granzyme-B-Cre	The Jackson Laboratory	JAX: 003734
Mouse: C57BL/6J	The Jackson Laboratory	JAX: 000664
Mouse: Tg(TcrLCMV)327Sdz (P14)	Pircher et al., 1989	MGI: 2665105
Mouse: Arid1atm1.1Mag	Chandler et al., 2015	MGI: 5708705
Mouse: Tbx21 KO	Szabo et al., 2002	JAX: 004648
Oligonucleotides
Recombinant DNA
MIGR1-Tbet	Joshi et al., 2007	NA
Software and algorithms
STAR	Dobin et al, 2013	https://github.com/alexdobin/STAR
bwa-mem2	Vasimuddin et al., 2019	https://github.com/bwa-mem2/bwa-mem2
Homer	Heinz et al., 2010	http://homer.ucsd.edu/homer/
DESeq2	Love et al., 2014	https://bioconductor.org/packages/release/bioc/html/DESeq2.html
ggplot2		https://cran.r-proiect.org/web/packages/ggplot2/index.html
deepTools	Ramírez et al., 2016	https://github.com/deeptools/deepTools/
fgsea		https://github.com/ctlab/fgsea