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SOCE-initiated signaling pathways in podocytes. In diabetic nephropathy and many other kidney diseases, the activities of one or more of these pathways are upregulated and the increased signaling results in podocyte injury. Broken arrows: putative triggers of the signaling pathways.
EMT: epithelial–mesenchymal transition; ER: endoplasmic reticulum; SOCE: store-operated Ca2+ entry; STIM1: stromal interaction molecule 1.
