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Treatment algorithm. MAO-B: monoamine oxidase-B; COMTI: catechol-o-methyl transferase inhibitors; DA: dopamine agonist; FD: functional disability. aAt the present state of knowledge, sooner or later, all subjects with PD will need levodopa treatment; there is no compelling reason to avoid prescribing levodopa from the early stages of the disease or to delay its introduction at the expense of the subject‘s functionality.
