Appendix 1—table 5. Adjusted regression coefficients and measures of significance of models with interaction term of baseline social isolation with change in age.
| dv | Model | Predictor | Estimate | 95% CI | p-value | FDR | BF | Total n | n individuals |
|---|---|---|---|---|---|---|---|---|---|
| Hippo campal volume |
1 | LSNS_base*age_change | –0.319 | –0.821, 0.182 | 0.1063 | 0.1821 | 0.16 | 1667 | 1306 |
| LSNS_base | –5.331 | −9.022,–1.64 | 1667 | 1306 | |||||
| LSNS_change | –5.570 | −9.227,–1.909 | 1667 | 1306 | |||||
| age_base | -26.052 | −28.905,–23.199 | 1667 | 1306 | |||||
| age_change | –22.528 | −29.639,–15.409 | 1667 | 1306 | |||||
| gender | –46.176 | −83.284,–9.069 | 1667 | 1306 | |||||
| 2 | LSNS_base*age_change | –0.302 | -0.833, 0.228 | 0.132 | 0.1981 | 0.15 | 1556 | 1226 | |
| LSNS_base | –5.423 | −9.315,–1.531 | 1556 | 1226 | |||||
| LSNS_change | –5.369 | −9.23,–1.503 | 1556 | 1226 | |||||
| age_base | –24.219 | −27.266,–21.173 | 1556 | 1226 | |||||
| age_change | -22.738 | −30.287,–15.179 | 1556 | 1226 | |||||
| gender | –46.042 | −84.16,–7.926 | 1556 | 1226 | |||||
| BMI | 13.544 | -3.326, 30.417 | 1556 | 1226 | |||||
| CESD | 12.301 | -6.982, 31.583 | 1556 | 1226 | |||||
| diabetes | –99.378 | −151.839,–46.907 | 1556 | 1226 | |||||
| education | -93.471 | −155.947,–30.99 | 1556 | 1226 | |||||
| hypertension | –21.032 | –61.396, 19.335 | 1556 | 1226 | |||||
| Executive functions | 1 | LSNS_base*age_change | 0.001 | –0.002, 0.003 | 0.6739 | 0.6739 | 0.08 | 2048 | 1469 |
| LSNS_base | –0.029 | −0.039,–0.019 | 2048 | 1469 | |||||
| LSNS_change | –0.002 | –0.017, 0.014 | 2048 | 1469 | |||||
| age_base | –0.019 | −0.026,–0.012 | 2048 | 1469 | |||||
| age_change | –0.057 | −0.09,–0.025 | 2048 | 1469 | |||||
| gender | -0.084 | –0.176, 0.008 | 2048 | 1469 | |||||
| 2 | LSNS_base*age_change | 0.001 | -0.001, 0.003 | 0.7713 | 0.7713 | 0.08 | 1893 | 1377 | |
| LSNS_base | –0.018 | −0.028,–0.008 | 1893 | 1377 | |||||
| LSNS_change | 0.004 | -0.012, 0.019 | 1893 | 1377 | |||||
| age_base | –0.014 | −0.021,–0.007 | 1893 | 1377 | |||||
| age_change | –0.063 | −0.097,–0.029 | 1893 | 1377 | |||||
| gender | –0.123 | −0.216,–0.029 | 1893 | 1377 | |||||
| BMI | -0.074 | -0.12, -0.028 | 1893 | 1377 | |||||
| CESD | –0.141 | −0.188,–0.094 | 1893 | 1377 | |||||
| diabetes | –0.056 | –0.185, 0.073 | 1893 | 1377 | |||||
| education | –0.331 | −0.488,–0.173 | 1893 | 1377 | |||||
| hypertension | -0.098 | –0.196, 0.001 | 1893 | 1377 | |||||
| Memory | 1 | LSNS_base*age_change | 0.000 | –0.002, 0.002 | 0.6695 | 0.6739 | 0.07 | 1921 | 1408 |
| LSNS_base | -0.015 | −0.023,–0.006 | 1921 | 1408 | |||||
| LSNS_change | -0.018 | −0.032,–0.005 | 1921 | 1408 | |||||
| age_base | -0.035 | −0.042,–0.029 | 1921 | 1408 | |||||
| age_change | –0.024 | –0.052, 0.005 | 1921 | 1408 | |||||
| gender | –0.382 | −0.466,–0.298 | 1921 | 1408 | |||||
| 2 | LSNS_base*age_change | 0.001 | –0.001, 0.003 | 0.7271 | 0.7713 | 0.08 | 1777 | 1315 | |
| LSNS_base | –0.008 | –0.018, 0.001 | 1777 | 1315 | |||||
| LSNS_change | –0.016 | −0.031, –0.002 | 1777 | 1315 | |||||
| age_base | -0.033 | –0.04, –0.026 | 1777 | 1315 | |||||
| age_change | -0.027 | –0.057, 0.003 | 1777 | 1315 | |||||
| gender | -0.421 | −0.507, –0.335 | 1777 | 1315 | |||||
| BMI | -0.031 | –0.074, 0.011 | 1777 | 1315 | |||||
| CESD | –0.120 | −0.164, –0.077 | 1777 | 1315 | |||||
| diabetes | –0.038 | –0.156, 0.08 | 1777 | 1315 | |||||
| education | –0.173 | −0.316, –0.031 | 1777 | 1315 | |||||
| hypertension | 0.017 | -0.074, 0.108 | 1777 | 1315 | |||||
| Processing speed | 1 | LSNS_base*age_change | -0.001 | –0.003, 0.001 | 0.2341 | 0.3122 | 0.19 | 2043 | 1470 |
| LSNS_base | -0.017 | −0.025, –0.009 | 2043 | 1470 | |||||
| LSNS_change | –0.008 | –0.022, 0.005 | 2043 | 1470 | |||||
| age_base | –0.038 | −0.044, –0.032 | 2043 | 1470 | |||||
| age_change | –0.027 | –0.057, 0.002 | 2043 | 1470 | |||||
| gender | –0.107 | −0.185, –0.03 | 2043 | 1470 | |||||
| 2 | LSNS_base*age_change | 0.000 | –0.002, 0.002 | 0.4856 | 0.6474 | 0.11 | 1888 | 1376 | |
| LSNS_base | –0.017 | −0.026, –0.008 | 1888 | 1376 | |||||
| LSNS_change | –0.008 | -0.022, 0.006 | 1888 | 1376 | |||||
| age_base | –0.036 | −0.042, –0.029 | 1888 | 1376 | |||||
| age_change | –0.033 | −0.063, 0.003 | 1888 | 1376 | |||||
| gender | –0.124 | −0.204, –0.044 | 1888 | 1376 | |||||
| BMI | –0.013 | –0.053, 0.028 | 1888 | 1376 | |||||
| CESD | –0.027 | –0.067, 0.013 | 1888 | 1376 | |||||
| diabetes | –0.004 | –0.115, 0.106 | 1888 | 1376 | |||||
| education | –0.115 | –0.248, 0.017 | 1888 | 1376 | |||||
| hypertension | –0.067 | –0.151, 0.018 | 1888 | 1376 |
full model1: dv~LSNS_base+LSNS_change+age_base+age_change+gender.
full model2: model1 +hypertension + diabetes +education + BMI +CESD.
dv, dependent variable; CI, confidence interval; FDR, p-values after FDR-correction; BF, Bayes factor in favour of alternative hypothesis; total n, total number of observations; n individuals, number of participants; LSNS_base, baseline Lubben Social Network Score; LSNS_change, change in Lubben Social Network Score; CESD, Center for Epidemiological Studies-Depression.