Appendix 1—table 7. Indirect effects of social isolation on hippocampal volume and cognitive functions.

Mediator	dv	Model	Estimate	SE	z-value	p-value
TICS	Hippo campal volume	1	0.0291	0.7414	0.0393	0.5157
		2	–0.2059	1.0916	–0.1886	0.4252
Hippo campal volume	Executive functions	1	–0.0008	0.0012	–0.6561	0.2559
		2	–0.0011	0.0013	–0.8066	0.2099
	Memory	1	–0.0008	0.0012	–0.6945	0.2437
		2	–0.0014	0.0015	–0.9245	0.1776
	Processing speed	1	-0.0001	0.0005	–0.2469	0.4025
		2	–0.0001	0.0007	–0.1648	0.4345

model1: corrected for baseline age, change in age and gender.

model2: model1 + hypertension + diabetes +education + BMI +CESD.

dv, dependent variable; SE, standard error; TICS, Trierer Inventar zum chronischen Stress (stress questionnaire).