Appendix 1—table 9. Adjusted regression coefficients and measures of significance of models using fewer exclusion criteria.
| dv | Model | Predictor | Estimate | 95% CI | p-value | FDR | BF | Total n | n individuals |
|---|---|---|---|---|---|---|---|---|---|
| Hippo campal volume |
1 | LSNS_base | –5.362 | −9.037,–1.687 | 0.0021** | 0.0051** | 12.35** | 1667 | 1309 |
| LSNS_change | –4.206 | −7.616,–0.788 | 0.008** | 0.0137* | 1.17 | 1667 | 1309 | ||
| age_base | -26.194 | −29.056,–23.333 | 1667 | 1309 | |||||
| age_change | –26.655 | −28.851,–24.465 | 1667 | 1309 | |||||
| gender | –46.466 | −83.665,–9.267 | 1667 | 1309 | |||||
| 2 | LSNS_base | –5.428 | −9.315,–1.541 | 0.0031** | 0.0094** | 10.11** | 1556 | 1232 | |
| LSNS_change | –4.368 | −8.04,–0.686 | 0.01* | 0.0201* | 1.6 | 1556 | 1232 | ||
| age_base | –24.542 | −27.6,–21.486 | 1556 | 1232 | |||||
| age_change | –26.819 | −29.198,–24.45 | 1556 | 1232 | |||||
| gender | –48.740 | −86.973,–10.506 | 1556 | 1232 | |||||
| BMI | 10.301 | -6.446, 27.053 | 1556 | 1232 | |||||
| CESD | 12.673 | –6.798, 32.143 | 1556 | 1232 | |||||
| diabetes | –96.009 | −148.633,–43.372 | 1556 | 1232 | |||||
| education | –90.854 | −153.471,–28.23 | 1556 | 1232 | |||||
| hypertension | –24.435 | -64.91, 16.046 | 1556 | 1232 | |||||
| Executive functions | 1 | LSNS_base | -0.030 | -0.038, -0.022 | 2.4e-13**** | 2.8e-12**** | 3.4e+10**** | 2551 | 1756 |
| LSNS_change | –0.009 | –0.021, 0.003 | 0.0776 | 0.1146 | 0.49 | 2551 | 1756 | ||
| age_base | –0.018 | −0.024,–0.012 | 2551 | 1756 | |||||
| age_change | -0.051 | −0.059,–0.042 | 2551 | 1756 | |||||
| gender | -0.112 | −0.194,–0.03 | 2551 | 1756 | |||||
| 2 | LSNS_base | –0.019 | −0.027,–0.011 | 5.6e-06**** | 6.7e-05**** | 3.8e+03**** | 2365 | 1649 | |
| LSNS_change | -0.005 | -0.018, 0.007 | 0.198 | 0.264 | 0.3 | 2365 | 1649 | ||
| age_base | –0.011 | −0.018,–0.005 | 2365 | 1649 | |||||
| age_change | –0.052 | −0.061,–0.043 | 2365 | 1649 | |||||
| gender | –0.160 | −0.244,–0.077 | 2365 | 1649 | |||||
| BMI | –0.052 | −0.093,–0.01 | 2365 | 1649 | |||||
| CESD | -0.137 | −0.179,–0.095 | 2365 | 1649 | |||||
| diabetes | -0.040 | -0.153, 0.073 | 2365 | 1649 | |||||
| education | -0.315 | -0.45, -0.18 | 2365 | 1649 | |||||
| hypertension | -0.102 | -0.191, -0.014 | 2365 | 1649 | |||||
| Memory | 1 | LSNS_base | –0.014 | −0.021,–0.006 | 2e-04**** | 7e-04**** | 120.88**** | 2418 | 1697 |
| LSNS_change | –0.016 | −0.027,–0.005 | 0.0017** | 0.0051** | 10.58** | 2418 | 1697 | ||
| age_base | –0.036 | −0.042,–0.03 | 2418 | 1697 | |||||
| age_change | –0.024 | −0.031,–0.016 | 2418 | 1697 | |||||
| gender | –0.383 | −0.459,–0.306 | 2418 | 1697 | |||||
| 2 | LSNS_base | -0.006 | –0.014, 0.002 | 0.0818 | 0.1403 | 0.68 | 2246 | 1590 | |
| LSNS_change | –0.015 | −0.026,–0.003 | 0.0057** | 0.0136* | 5.02* | 2246 | 1590 | ||
| age_base | –0.033 | −0.04,–0.027 | 2246 | 1590 | |||||
| age_change | –0.025 | −0.034,–0.017 | 2246 | 1590 | |||||
| gender | –0.429 | −0.508,–0.351 | 2246 | 1590 | |||||
| BMI | –0.030 | -0.068, 0.009 | 2246 | 1590 | |||||
| CESD | –0.133 | −0.172,–0.093 | 2246 | 1590 | |||||
| diabetes | –0.067 | –0.172, 0.038 | 2246 | 1590 | |||||
| education | -0.148 | −0.272,–0.023 | 2246 | 1590 | |||||
| hypertension | 0.032 | –0.052, 0.115 | 2246 | 1590 | |||||
| Processing speed | 1 | LSNS_base | –0.016 | −0.023,–0.009 | 1.9e-06**** | 1.1e-05**** | 7.7e+03**** | 2552 | 1749 |
| LSNS_change | -0.014 | −0.025,–0.003 | 0.0047** | 0.0093** | 4.61* | 2552 | 1749 | ||
| age_base | –0.038 | −0.044,–0.033 | 2552 | 1749 | |||||
| age_change | –0.037 | −0.045,–0.029 | 2552 | 1749 | |||||
| gender | –0.096 | −0.163,–0.028 | 2552 | 1749 | |||||
| 2 | LSNS_base | –0.013 | −0.02,–0.006 | 2e-04**** | 0.0011** | 162.63**** | 2366 | 1640 | |
| LSNS_change | –0.016 | −0.027,–0.005 | 0.0023** | 0.0092** | 10.97** | 2366 | 1640 | ||
| age_base | –0.036 | −0.041,–0.03 | 2366 | 1640 | |||||
| age_change | –0.036 | −0.044,–0.028 | 2366 | 1640 | |||||
| gender | –0.116 | −0.186,–0.045 | 2366 | 1640 | |||||
| BMI | –0.021 | –0.056, 0.014 | 2366 | 1640 | |||||
| CESD | –0.037 | −0.073,–0.002 | 2366 | 1640 | |||||
| diabetes | –0.025 | –0.121, 0.07 | 2366 | 1640 | |||||
| education | –0.172 | −0.284,–0.06 | 2366 | 1640 | |||||
| hypertension | –0.049 | –0.123, 0.026 | 2366 | 1640 |
full model1: dv~LSNS_base +LSNS_change +age_base +age_change +gender.
full model2: model1 +hypertension + diabetes +education + BMI +CESD.
The unit of effect sizes on hippocampal volume and cognitive functions are mm³/point on the LSNS and standard deviation/point on the LSNS, respectively.
* p<0.05, BF >3; ** p<0.01, BF >10; *** p<0.001, BF >30; **** p<0.0001, BF >100.
dv, dependent variable; CI, confidence interval; FDR, p-values after FDR-correction; BF, Bayes factor in favour of alternative hypothesis; total n, total number of observations; n individuals, number of participants; LSNS_base, baseline Lubben Social Network Score; LSNS_change, change in Lubben Social Network Score; CESD, Center for Epidemiological Studies-Depression.