Table 2.

Multivariable models

Variable	DM		PCSM		OS
Hazard Ratio (95% CI), P-value
GC score	1.22 (1.09 - 1.36)	<0.001*	1.23 (1.09 - 1.39)	<0.001*	1.12 (1.05 - 1.20)	0.001*
Age	1.00 (0.96 - 1.04)	0.98	1.00 (0.96 - 1.04)	0.97	1.07 (1.04 - 1.10)	<0.001*
Log2 pre-treatment PSA	0.99 (0.80 - 1.22)	0.91	0.96 (0.78 - 1.18)	0.68	1.01 (0.88 - 1.15)	0.90
T3-T4 vs. T1-T2	1.52 (0.89 - 2.62)	0.13	1.40 (0.80 - 2.43)	0.24	1.19 (0.85 - 1.67)	0.30
Gleason 8-10 vs. <8	2.46 (1.41 – 4.31)	0.002*	1.31 (0.73 – 2.36)	0.36	1.40 (0.99 – 1.99)	0.06

Hazard ratios of genomic classifiers were per 0.1 unit increased. Strata = original arm. Death as a competing risk for DM and PCSM.