Table 4:
Prostate cancer study analysis results based on logistic regression (n = 1014).
| Without calculators | With PBCG calculator | With PBCG-2 calculator | With both calculators | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| est | s.e. | p | est | s.e. | p | est | s.e. | p | est | s.e. | p | |
| Intercept | −7.421 | 0.769 | < 0.001 | −6.802 | 0.227 | < 0.001 | −7.276 | 0.315 | < 0.001 | −6.826 | 0.229 | < 0.001 |
| log2(PSA) | 0.595 | 0.119 | < 0.001 | 0.756 | 0.033 | < 0.001 | 0.774 | 0.051 | < 0.001 | 0.751 | 0.033 | < 0.001 |
| age | 0.037 | 0.011 | 0.001 | 0.027 | 0.004 | < 0.001 | 0.036 | 0.005 | < 0.001 | 0.028 | 0.004 | < 0.001 |
| DRE | 0.635 | 0.210 | 0.003 | 0.769 | 0.057 | < 0.001 | 0.631 | 0.199 | 0.001 | 0.762 | 0.057 | < 0.001 |
| biopsy | −0.895 | 0.245 | < 0.001 | −0.938 | 0.058 | < 0.001 | −0.901 | 0.216 | < 0.001 | −0.943 | 0.058 | < 0.001 |
| race | 0.090 | 0.341 | 0.793 | 0.192 | 0.103 | 0.062 | −0.050 | 0.120 | 0.675 | 0.181 | 0.103 | 0.079 |
| history | 0.248 | 0.209 | 0.235 | 0.413 | 0.049 | < 0.001 | 0.249 | 0.191 | 0.193 | 0.414 | 0.049 | < 0.001 |
| PCA3 | 0.347 | 0.062 | < 0.001 | 0.347 | 0.057 | < 0.001 | 0.347 | 0.056 | < 0.001 | 0.345 | 0.057 | < 0.001 |
| T2ERG | 0.565 | 0.183 | 0.002 | 0.567 | 0.166 | 0.001 | 0.568 | 0.165 | 0.001 | 0.582 | 0.166 | < 0.001 |
est: estimated value. s.e.: standard error. p: p-value. DRE: a binary indicator of an abnormal digital rectal exam. biopsy: a binary indicator of prior negative biopsy. race: a binary indicator of African Ancestry. history: a binary indicator of first-degree family history of prostate cancer. PCA3: log2(PCA3 + 1). T2ERG: dichotomized TMPRSS2:ERG split at the median