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. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: Trends Biochem Sci. 2022 May 23;47(11):978–988. doi: 10.1016/j.tibs.2022.05.001

Figure 3. Structural similarities of mammalian double-stranded RNA (dsRNA)-binding viral suppressors of RNAi (VSRs).

Figure 3.

The dsRNA-binding domain (dsRBD) of NS1 (left) and B2 (right) drawn in a cartoon style along with the structures in their space-filling representation, with charged amino acids colored in red for acidic amino acids Asp and Glu and blue for basic amino acids Arg, Lys, and His (right panels). Reprinted, with permission, from [58]. Similar to FHV B2 (right), the 2.5 Å crystal structure of the dsRBD of NoV B2 also shows a four-helix bundle structure capped by two short helices at the C-termini [58].