Skip to main content
. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: Trends Biochem Sci. 2022 May 23;47(11):978–988. doi: 10.1016/j.tibs.2022.05.001

Table 2.

Mammalian RNA viral proteins that exhibit viral suppressor of RNAi activity

VSR Virus Family (genome type) Putative mechanism Refs
7a SARS-CoV-1 Coronaviridae (+RNA) Unknown [69]
N (nucleocapsid) SARS-CoV-1/2 Coronaviridae (+RNA) dsRNA sequestration [70,71]
NS4B Dengue virus 1–4 Flaviviridae (+RNA) Unknown [72]
Capsid Zika/yellow fever virus Flaviviridae (+RNA) dsRNA sequestration [73–75]
Capsid; NS2 Hepatitis C virus Flaviviridae (+RNA) Dicer binding; dsRNA sequestration [76,77]
Capsid Semliki Forest virus Togaviridae (+RNA) dsRNA sequestration [78]
Capsid Rubella virus Matonaviridae (+RNA) dsRNA sequestration [79]
nsP2; nsP3 Chikungunya virus Togaviridae (+RNA) Unknown [80]
VP30; VP35; VP40 Ebola virus Filoviridae. (−RNA) Dicer binding; dsRNA sequestration; unknown [11,13,41,81]
VP35 Marburg virus Filoviridae. (−RNA) dsRNA sequestration [13]
NSsa La Crosse virus Bunyaviridae (−RNA) Unknown [82]
a

Homologous NS protein encoded by a member of the same virus family that infects plants is also a VSR to promote in vivo infection by suppressing antiviral RNAi [83,84].