Figure 2.

Mice with renal tubule-selective transient receptor potential vanilloid type 4 (TRPV4) deletion exhibit increased plasma K⁺ levels on low and high K⁺ intake. Shown is a summary graph of plasma K⁺ levels in TRPV4^fl/fl (red) and TRPV4^fl/fl-Pax8Cre (green) mice kept on low (<0.01% K⁺), regular (0.9% K⁺), and high (5% K⁺) K⁺ intake for 7 days. Males and females are indicated as triangles and circles, respectively (6 female mice and 6 male mice in each group). *Significant increase (P < 0.05, one-way ANOVA with a post hoc Tukey’s test) vs. respective values of TRPV4^fl/fl mice, as indicated by the horizontal bars. Supplemental Fig. S3 provides verification of the lack of hemolysis in the tested samples.