Figure 3.

Mice with transient receptor potential vanilloid type 4 (TRPV4) deletion in the renal tubule demonstrate transient-deficient kaliuresis to dietary K⁺ load. Summary graphs showing the comparison of 24-h urinary K⁺ levels (A) and urinary volume (B) in TRPV4^fl/fl mice (red, 2 females and 6 males) and TRPV4^fl/fl-Pax8Cre mice (green, 4 females and 6 males) maintained on a regular-K⁺ diet (0.9% K⁺) and in response to a high-K⁺ diet (5% K⁺) for 1, 2, and 7 days. Each dot represents a measurement from an individual animal. Males and females are indicated as triangles and circles, respectively. *Significant changes (P < 0.05, one-way ANOVA with a post hoc Tukey’s test) vs. the respective values of TRPV4^fl/fl mice, as indicated by the horizontal bars.