Figure 4.

Chronic dietary K⁺ load increases urinary aldosterone levels in mice with transient receptor potential vanilloid type 4 (TRPV4) deletion in the renal tubule. Shown is a summary graph of comparison of 24-h urinary aldosterone in TRPV4^fl/fl mice (red, 2 females and 3 males) and TRPV4^fl/fl-Pax8Cre mice (green, 2 females and 3 males) maintained on a regular-K⁺ diet (0.9% K⁺) and in response to a high-K⁺ diet (5% K⁺) for 1, 2, and 7 days. Each dot represents a measurement from an individual animal. Males and females are indicated as triangles and circles, respectively. *Significant increase (P < 0.05, one-way ANOVA with a post hoc Tukey’s test) vs. the respective values of TRPV4^fl/fl mice, as indicated by the horizontal bars.