Figure 6.

Transient receptor potential vanilloid type 4 (TRPV4)^fl/fl-Pax8Cre mice demonstrate sustained augmented renal K⁺ conservation in response to systemic K⁺ deficiency. Summary graphs showing a comparison of 24-h urinary K⁺ levels (A) and urinary volume (B) in TRPV4^fl/fl mice (red, 4 females and 6 males) and TRPV4^fl/fl-Pax8Cre mice (green, 2 females and 7 males) maintained on a regular-K⁺ diet (0.9% K⁺) and in response to a low-K⁺ diet (<0.01% K⁺) for 1, 2, and 7 days. Each dot represents a measurement from an individual animal. Males and females are indicated as triangles and circles, respectively. *Significant changes (P < 0.05, one-way ANOVA with a post hoc Tukey’s test) vs. the respective values of TRPV4^fl/fl mice, as indicated by the horizontal bar.