Table 2.
Plasma lipid data of survivor and nonsurvivor groups.
| Variable (nM) | D1 | D7 | D7-D1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Survivors (n = 25) | Nonsurvivors (n = 15) | p-value | Survivors (n = 25) | Nonsurvivors (n = 8) | p-value | Survivors (n = 25) | Nonsurvivors (n = 8) | p-value | |
| 16 : 0 LysoPC | 47645.79 (31495.28–89381.93) | 54143.53 (24175.21–110959.19) | 0.900 | 117402.86 (76388.19–153896.00) | 38892.97 (26863.80–109655.06) | 0.017∗ | 45344.39 (22450.94–88171.33) | 5273.77 (−24878.11–57746.44) | 0.048∗ |
| 14 : 0 LysoPC | 562.61 (443.30–625.22) | 544.81 (387.80–674.52) | 0.727 | 854.10 (691.57–1058.04) | 731.14 (515.61–927.74) | 0.193 | 292.74 (98.52–512.49) | 89.55 (0.80–163.51) | 0.153 |
| 15 : 0 LysoPC | 566.46 (442.74–668.70) | 594.59 (412.87–720.05) | 0.769 | 889.98 (635.55–985.57) | 716.97 (553.37–812.88) | 0.153 | 206.08 (75.76–464.47) | 83.36 (−14.53–159.54) | 0.110 |
| 17 : 0 LysoPC | 554.96 (380.61–739.33) | 517.30 (341.62–855.38) | 0.685 | 858.26 (672.48–1149.97) | 574.04 (430.60–686.53) | 0.005∗ | 275.04 (203.05–549.00) | −32.92 (−211.46–124.50) | 0.001∗ |
| 18 : 0 LysoPC | 6778.18 (3811.50–10874.18) | 7025.67 (2518.06–9248.98) | 0.586 | 13450.31 (9228.13–17360.12) | 5259.48 (3231.33–10666.63) | 0.004∗ | 5718.02 (2554.51–9075.89) | 120.06 (−2361.27–2198.87) | 0.010∗ |
| 18 : 1 LysoPC | 6022.53 (3553.98–8608.39) | 6224.57 (2203.90–10340.38) | 0.922 | 12912.09 (8657.25–17139.27) | 6056.01 (2494.34–14707.32) | 0.040∗ | 5435.26 (1390.30–12651.51) | 750.78 (−804.26–8620.02) | 0.179 |
| 20 : 4 LysoPI | 722.37 (445.65–1308.57) | 780.50 (451.08–2158.25) | 0.349 | 699.68 (438.84–1293.19) | 651.92 (391.67–1176.63) | 0.501 | −38.40 (−187.64–78.05) | −25.59 (−57.42–344.32) | 0.294 |
| 18 : 0 PE | 1493.12 (1201.51–2745.27) | 2280.28 (1445.53–3225.21) | 0.167 | 2142.35 (1595.05–3186.86) | 3664.51 (2875.74–6476.39) | 0.036∗ | 507.00 (139.72–4095.54) | 729.71 (−298.53–4177.34) | 0.867 |
| 16:0–18 : 1 PE | 3491.63 (2551.85–5749.08) | 6750.93 (3238.72–8458.05) | 0.158 | 3725.58 (2051.79–7734.99) | 10951.61 (4649.92–16254.12) | 0.019∗ | 447.28 (−1202.71–4095.54) | 6806.34 (489.33–9295.82) | 0.059 |
| 16:0–18 : 2 PE | 5971.65 (4667.43–12012.34) | 14213.70 (10082.27–19008.73) | 0.026∗ | 6335.59 (3940.83–19357.27) | 17851.65 (9616.94–41152.45) | 0.053 | 1834.57 (−1665.37–8588.23) | 8366.01 (1089.32–21130.06) | 0.193 |
| 16:0–20 : 4 PE | 6264.81 (4058.03–12709.27) | 9581.70 (6905.14–13060.32) | 0.150 | 7692.52 (4141.69–14919.92) | 12910.23 (7285.30–22963.00) | 0.223 | 734.46 (−1914.44–5549.51) | 5083.14 (−955.67–8134.60) | 0.334 |
| 16:0–22 : 6 PE | 19348.42 (12947.13–46886.62) | 37492.20 (23092.63–50996.44) | 0.214 | 28178.89 (13008.68–59176.73) | 59446.43 (22453.56–73603.91) | 0.223 | 5614.04 (−5768.61–35450.20) | 22605.58 (4309.01–38569.88) | 0.257 |
| 18:0–18 : 2 PE | 12733.97 (10594.57–20815.69) | 23814.87 (20595.80–46621.78) | 0.017∗ | 15494.19 (10115.09–33258.62) | 38422.61 (20754.93–59676.60) | 0.053 | 3390.22 (−1419.69–14017.09) | 5849.92 (−3689.90–34346.29) | 0.737 |
| 18:0–20 : 4 PE | 195308.16 (144022.72–316482.95) | 322636.03 (234243.32–401924.15) | 0.142 | 248414.01 (120406.60–394477.35) | 343228.72 (185468.10–448939.29) | 0.294 | 3271.57 (−48274.87–173536.48) | 21496.88 (−60103.70–115631.77) | 0.933 |
| 18:0–22 : 6 PE | 7224.19 (5100.28–16136.85) | 11880.36 (4813.88–16899.79) | 0.426 | 9161.84 (4877.97–18786.07) | 17835.56 (12013.79–22761.61) | 0.141 | 1937.65 (−2091.67–11920.19) | 6545.06 (803.73–10169.62) | 0.501 |
| 14 : 0 LysoPE | 555.99 (334.27–3484.52) | 353.11 (259.18–1532.81) | 0.476 | 443.99 (193.15–2703.23) | 2742.10 (456.81–13156.82) | 0.101 | −119.46 (−405.53–513.47) | 1835.86 (−78.69–8644.08) | 0.085 |
| 16 : 0 LysoPE | 4453.28 (2364.01–8896.05) | 5100.30 (2747.04–9349.86) | 0.856 | 8210.14 (4510.54–10939.53) | 8208.28 (5078.70–10758.13) | 0.966 | 3461.40 (703.63–7092.41) | 2596.76 (1621.38–5808.26) | 0.900 |
| 18 : 0 LysoPE | 1826.52 (1413.53–3211.28) | 1809.18 (1016.44–3238.54) | 0.511 | 3826.56 (2331.47–4850.50) | 2180.73 (1250.18–3159.32) | 0.036∗ | 1006.70 (17.66–2485.23) | 605.07 (−270.03–1262.71) | 0.425 |
| 18 : 1 LysoPE | 2097.79 (939.33–4891.90) | 2431.32 (653.89–4078.73) | 0.944 | 3360.97 (2614.74–5520.26) | 5256.52 (2591.47–9697.28) | 0.529 | 1998.87 (−399.72–2639.20) | 1542.73 (288.15–7518.27) | 0.834 |
| 15 : 0 PC | 4085.07 (2926.55–5553.55) | 4349.65 (2461.94–5276.59) | 0.989 | 3801.10 (2327.55–5570.09) | 4288.43 (2942.47–6122.28) | 0.674 | −131.06 (−1102.35–1590.94) | 1229.49 (−1355.13–1870.44) | 0.401 |
| 16 : 0 PC | 29703.76 (25474.95–42230.58) | 35894.33 (22077.55–48070.41) | 0.494 | 30432.44 (24713.70–40188.12) | 30571.81 (20737.63–36444.16) | 0.585 | 609.53 (−4776.65–4269.97) | −2842.23 (−9211.40–1481.85) | 0.355 |
| 17 : 0 PC | 22393.56 (6104.38–39570.25) | 31940.92 (4004.49–44439.10) | 0.605 | 25331.06 (7159.97–42717.74) | 22169.66 (3396.93–54568.61) | 0.705 | 871.32 (−2114.08–3755.21) | 601.81 (−118.18–11814.62) | 0.585 |
| 16 : 1 (Δ9–Cis) PC | 2035.07 (1139.23–3367.16) | 2219.49 (1406.17–4142.06) | 0.364 | 2347.80 (1563.95–4028.63) | 2473.91 (1485.48–5075.80) | 0.933 | 725.71 (−297.81–1478.72) | 499.71 (−226.39–1347.20) | 0.644 |
| 18 : 1 (Δ6–Cis) PC | 261178.44 (195560.70–355721.48) | 339413.93 (2493.18–443771.49) | 0.150 | 329095.33 (235899.83–400610.19) | 221229.71 (184490.45–391672.19) | 0.257 | 56856.96 (−50362.91–129076.83) | −62696.57 (−257199.48–2990.53) | 0.017∗ |
| 18 : 2 (Cis) PC (DLPC) | 184199.14 (13610.08–301147.62) | 202776.66 (29317.93–379207.71) | 0.459 | 176871.95 (25541.39–301606.26) | 59002.20 (10548.48–240050.72) | 0.193 | −267.98 (−34042.76–14970.49) | 325.01 (−49320.78–43124.56) | 0.933 |
| 20 : 4 (CisPC | 950.81 (711.96–1284.71) | 1017.86 (880.51–1352.09) | 0.748 | 1291.29 (1074.31–1633.81) | 764.50 (344.66–984.90) | 0.001∗ | 359.83 (−64.11–658.44) | −9.08 (−134.27–43.44) | 0.032∗ |
| 16:0–18 : 1 PC | 367968.93 (293044.87–478156.82) | 407921.85 (339975.21–611837.27) | 0.258 | 393292.77 (244105.72–609542.74) | 503048.65 (373013.97–624819.66) | 0.334 | 59498.46 (−68655.93–183371.08) | 58029.25 (30467.89–201823.68) | 0.450 |
| 18:0–22 : 6 PC | 12707.22 (8572.14–15919.73) | 11393.47 (7586.36–14668.03) | 0.426 | 12586.54 (7885.99–17052.51) | 9246.98 (3893.92–11631.45) | 0.032∗ | −424.36 (−3051.63–5472.86) | −3238.85 (−5093.89–182.75) | 0.093 |
| 18:1–18 : 0 PC | 30919.73 (24618.95–39336.74) | 31332.57 (27753.23–43794.64) | 0.567 | 46915.50 (34774.84–61301.82) | 48831.19 (37985.70–54468.56) | 0.769 | 7093.81 (1054.35–28166.38) | 11643.09 (−876.27–18644.37) | 0.737 |
| 16 : 0 SM | 240873.95 (76481.33–311554.44) | 305080.43 (85113.52–361243.22) | 0.194 | 238174.68 (76941.20–334210.42) | 131647.18 (43982.20–223070.37) | 0.053 | −8772.97 (−49228.81–22084.70) | −23679.46 (−36682.05–−7178.98) | 0.401 |
| 17 : 0 SM | 3509.81 (2278.21–4340.59) | 4147.07 (2107.43–5222.32) | 0.335 | 3581.18 (1931.35–4417.85) | 2358.71 (985.82–3560.52) | 0.110 | −57.00 (−841.94–441.83) | −569.16 (−724.59–70.64) | 0.208 |
| 18 : 0 SM | 36630.75 (18728.18–48618.78) | 34702.66 (16191.61–56476.49) | 0.685 | 28706.78 (15548.77–55309.55) | 16192.68 (5140.87–33252.71) | 0.110 | −3066.21 (−8039.50–6457.16) | −4126.86 (−6741.35–392.36) | 0.867 |
| 18 : 1 SM | 2868.66 (2164.78–5085.49) | 3437.40 (2846.27–4393.62) | 0.349 | 4009.61 (2562.18–5334.50) | 3056.94 (2224.28–3962.18) | 0.141 | 392.19 (−930.29–1880.62) | −1358.22 (−3028.30–328.19) | 0.023∗ |
| 24 : 0 SM | 17360.63 (11729.22–34205.97) | 30746.35 (15078.40–38704.38) | 0.185 | 20905.22 (12342.47–32776.33) | 19001.57 (5103.74–28461.75) | 0.378 | 70.05 (−5114.18–5536.13) | −4431.31 (−5523.38–8206.74) | 0.401 |
| 24 : 1 SM | 77329.53 (48739.03–150692.35) | 120008.44 (56023.29–171201.33) | 0.235 | 116073.97 (58571.47–165057.54) | 68616.14 (34768.06–154764.03) | 0.257 | 5636.92 (−17507.22–29374.29) | −11454.39 (−25321.07–60237.72) | 0.401 |
| 16 : 0 ceramide | 2934.78 (1677.44–4628.57) | 4020.45 (1231.47–5189.63) | 0.769 | 2661.30 (1284.48–3143.01) | 2554.08 (906.93–4054.96) | 0.801 | −641.42 (−1570.97–71.92) | −575.98 (−1272.81–−137.78) | 0.966 |
| 18 : 0 ceramide | 2001.39 (1061.58–3242.56) | 2212.33 (782.03–3023.55) | 0.791 | 1780.69 (1082.96–2499.12) | 1697.29 (720.56–3060.19) | 0.933 | −216.07 (−844.71–282.25) | −93.96 (−1404.07–360.25) | 0.867 |
| 18 : 1 ceramide | 911.56 (550.07–1300.82) | 1006.46 (536.90–1338.42) | 0.878 | 893.39 (549.48–1121.13) | 786.71 (526.98–1207.20) | 0.769 | −29.78 (−201.78–21.02) | −8.96 (−243.81–19.14) | 0.674 |
| 20 : 0 ceramide | 1658.83 (986.15–2092.05) | 1764.86 (920.03–2798.69) | 0.379 | 1355.39 (950.57–1830.90) | 1306.95 (743.49–2167.06) | 0.501 | −109.40 (−422.72–158.68) | −134.37 (−1159.48–−18.95) | 0.179 |
| 22 : 0 ceramide | 304.84 (267.70–443.87) | 337.13 (296.71–530.06) | 0.175 | 362.14 (254.03–527.38) | 376.95 (300.57–574.25) | 0.585 | −19.40 (−84.89–201.51) | −34.03 (−164.26–251.51) | 0.556 |
| 24 : 0 ceramide | 31362.79 (25605.08–42431.63) | 30447.84 (20865.83–45588.97) | 0.922 | 29859.38 (24106.03–40325.47) | 35167.62 (22076.35–45854.22) | 0.475 | −1021.46 (−8034.04–11936.68) | 2016.01 (−5911.50–5192.63) | 0.801 |
| 24 : 1 ceramide | 5527.79 (3948.79–7456.97) | 6419.72 (3379.74–11735.65) | 0.158 | 4532.09 (3229.22–7040.63) | 4173.49 (1575.18–10255.01) | 0.674 | 174.54 (−1881.11–1654.20) | −418.20 (−3031.20–912.74) | 0.529 |
P < 0.05 was considered statistically significant. D1, day 1; D7, day 7; DLPC, dioleoylphosphatidylcholine; PC, phosphatidylcholine; PE, phosphatidylethanolamines; PI, phosphatidylinositol; SM, sphingomyelin.