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. 2023 May 24;55(5):842–852. doi: 10.3724/abbs.2023049

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© The Author(s) 2021.

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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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ATM phosphorylation promotes tolerance of OS cells to irradiation

(A) CCK-8 assays showed that ATM, but not ATM-mut, promoted cell survival under conditions of 4 Gy irradiation. (B) Apoptosis assays revealed that if ATM couldn’t be phosphorylated and activated, it wouldn’t prevent OS cells apoptosis under irradiation. (C) Clonogenic assay demonstrated that compared with ATM overexpression, ATM-mut couldn’t rescue the clone formation ability of OS cells. Empty vector vs shATM ( ATM knockdown), ** P<0.01; ## P<0.01. CCK-8, clonogenic and apoptosis assays were repeated three times.