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. 2023 May 30;55(5):853–865. doi: 10.3724/abbs.2023058

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© The Author(s) 2021.

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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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EN460 (an ERO1 inhibitor) protects cells from erastin-induced ferroptosis

(A‒D) Levels of NO (A,B) and ROS (C,D) after treatment with 1 μM erastin± 40 μM EN460 for 8 h: fluorescence microscopy images (A,C) and quantitative intensity values (B,D). Scale bar: 45 μm. (E,F) Levels of lipid ROS after treatment with 1 μM erastin± 40 μM EN460 for 8 h: flow cytometry data (E), quantitative intensity values (F). (G) Cell viability change after treatment with 1 μM erastin± 40 μM EN460 for 24 h. Data are presented as the mean±SE. n=3. * P<0.05, ** P<0.01 vs the control group.