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. 2023 May 12;55(5):701–712. doi: 10.3724/abbs.2023086

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© The Author(s) 2021.

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This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/).

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The structure of the igf1 gene

Alternative splicing of the igf1 gene in rodents and human. The rodent and human genes both have 6 exons, and their translation arises from exon 1 or 2, respectively. In rodents (left), IGF-1Ea excludes exon 5, while IGF-1Eb has a premature termination of exon 6. In humans (right), IGF-1Ea has a similar pattern in humans and rodents; IGF-1Eb in humans excludes exon 6, and IGF-1Ec in humans includes an internal splice site within exon 5 and a premature termination in exon 6. “Pre” indicates the presence of a signal peptide, while “pro” indicates the presence of E-peptides.