Table 3.

Recall-relevant Common Terminology Criteria for Adverse Events (CTCAE) version 5.0

Term	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Radiation recall reaction (dermatologic)	Faint erythema or dry desquamation	Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema	Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion	Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated	Death
Dermatitis radiation	Faint erythema or dry desquamation	Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema	Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion	Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated	Death
Pneumonitis	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Symptomatic; medical intervention indicated; limiting instrumental ADL	Severe symptoms; limiting self-care ADL; oxygen indicated	Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)	Death
Myositis	Mild pain	Moderate pain associated with weakness; pain limiting instrumental ADL	Pain associated with severe weakness; limiting self-care ADL	Life-threatening consequences; urgent intervention indicated	–
Esophagitis	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Symptomatic; altered eating/swallowing; oral supplements indicated	Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated	Life-threatening consequences; urgent operative intervention indicated	Death
Proctitis	Rectal discomfort, intervention not indicated	Symptomatic (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL	Severe symptoms; fecal urgency or stool incontinence; limiting self-care ADL	Life-threatening consequences; urgent intervention indicated	Death

ADL activity of daily living, TPN total parenteral nutrition